Matsakaicin Sarka Triglycerides (MCT) Matsayin Magunguna | Maganin lipophilic & Mai ɗauke da Magunguna don Baki/Maganin Jiki/Allura | USP/EP/ChP

Triglycerides na Matsakaici a Matsayin Magunguna (MCT)

Bayanin Samfuri

Triglycerides na Matsakaici (MCT) wani sinadari ne da aka kafa a fannin magunguna wanda ya ƙunshi cakuda triglycerides na fatty acids masu cikakken kitse, galibi caprylic acid (C8H16O2, octanoic acid) da capric acid (C10H20O2, decanoic acid).Ana samun waɗannan triglycerides daga man da aka gyara da aka cire daga ƙashin tauri da busasshe na endosperm na kwakwa (Cocos nucifera L.) ko kuma daga busasshen endosperm na man dabino (Elaeis guineensis Jacq.)Ana raba fatty acids daga man kitse sannan a sake haɗa su da glycerol don samar da samfurin ƙarshe.

Asalin Samfuri:

• Sunan Sinadarai:Triglycerides Matsakaici-Sarkar Sarka / Caprylic/Capric Triglyceride

• Lambar CAS:73398-61-5 (kuma 85409-09-2 ko 538-24-9)

• Lambar Rijistar CDE:F20220000316

• Bin ƙa'idodin Pharmacopoeia:ChP (CP2020), USP-NF (Triglycerides na Matsakaici), EP (Triglycerides, Sarkar Matsakaici), JP (Triglycerides mai kitse mai matsakaici)

• Ma'ana iri ɗaya:Man MCT, Caprylic/Capric Triglyceride, Glycerides gauraye decanoyl da octanoyl, Miglyol® 812 daidai, daidai Labrafac™ CC

• Bayyanar:Ruwan mai mai-mai-mai-launi zuwa mai ɗan rawaya, kusan babu ƙamshi da ɗanɗano,

• Wurin Daskarewa:Kimanin 0°C

Muhimman Abubuwa & Fa'idodi

1. Halayen Mafi Kyau na Maganin Ƙarfi

• Mafi kyawun maganin lipophilic da APIs marasa narkewa cikin ruwa

• Yana inganta narkewa da daidaita mahaɗan lipophilic

• Yana inganta samuwar magungunan Aji na II da na Aji na IV (Rarraba BCS)

2. Sha da Sauri da kuma Metabolism

• Yana shiga cikin hanyoyin jini kai tsaye ba tare da buƙatar gishirin bile ko enzymes na pancreas ba

• Ana sarrafa shi cikin sauri don samar da kuzari mai sauri

• Saurin isar da API zuwa tsarin zagayawa, yana iya inganta fara aiki

3. Kyakkyawan Bayanin Kwanciyar Hankali

• Babban juriya ga iskar shaka (ƙimar aidin ≤1.0)

• Ƙananan sauƙin kamuwa da damuwa ta zafi da oxidative

• Yana kiyaye kwanciyar hankali da tsawon rayuwar magungunan da ake amfani da su

• Daidaitacce a yanayin zafi mai yawa (≤25°C an ba da shawarar)

4. Manyan Halayen Jiki

• Danko:~30 mPa·s a 20°C (ƙarancin ɗanko don sauƙin sarrafawa)

• Takamaiman Nauyi:0.93-0.96 a 20°C

• Ma'aunin Haske:1.440-1.452 a 20°C

• Ƙananan danko da ya dace da nau'ikan allurai na ruwa da semi-solid

5. Kyakkyawan Dacewa

• Mai jituwa tare da nau'ikan APIs da abubuwan haɗin magunguna iri-iri

• Ana iya haɗa shi cikin sauƙi cikin tsari daban-daban ba tare da matsalolin daidaitawa ba

• Ƙanshi da ɗanɗano marasa tsaka tsaki - ya dace da maganin baki inda sauƙin sha'awa yake da mahimmanci

6. Bayanin Dokoki da Tsaro

• Matsayin GRAS (Gabaɗaya An Gane Shi A Matsayin Amintacce)

• Ba mai guba ba, ba ya ƙaiƙayi ga fata da idanu

• LD50 (linzami, na baki): 29.6 g/kg – yana da matuƙar aminci

• An ƙera GMP tare da ingantaccen tsarin kula da inganci

• An yi rijistar CDE (F20220000316) don kasuwar Sin

• Akwai tare da tallafin ƙa'idoji don yin rajista na duniya